Chemical properties
Titanium is a Group IV transition metal, which exhibits a tetravalent state in solutions. The use of various chelators has been reported, but stable in vivo chelation is still challenging REF.
Nuclear properties
Ti-45 decays with a half-life of 3.08 hours by β+ decay (84.82(13)%) or electron capture (15.18%) to stable Sc-45.
Ti-45 emits γ-rays with low intensity besides the 511 keV annihilation γ-lines, where the 719.6 keV (0.154%) γ-ray has the highest intensity REF.
The total electron energy emitted per decay is 372 keV, the total photon energy per decay is 866 keV REF.
Production
Ti-45 is produced by proton irradiation of natural Sc targets at Hevesy Laboratory at DTU. A radiochemical Ti/Sc separation via extraction chromatography leads to n.c.a. Ti-45.
Distribution
Radiochemical separations are performed at Hevesy Laboratory (DTU, Risø, Denmark). Activity will be shipped from there to the users in form of Ti4+ in oxalic acid solution.
Examples of use
Ti-45 has been studied for PSMA-targeted imaging REF
| Parameter | Specifications |
|---|---|
| Production route | Sc-45(p,n)Ti-45 |
| Daughter | Decays to stable Sc-45: 84.8% (β+), 15.2% EC |
| Half-life | 3.08 h |
| Processing | Extraction chromatography |
| Primary Container | 2.5 mL borosilicate glass V-vial with silicone rubber screw cap |
| Product Grade | n.c.a |
| Physical Form | Liquid |
| Chemical Form | Ti4+ ion in oxalic acid solution |
| Radioactive Concentration (gamma spectrometry) | n.a. |
| Appearance | Clear colourless solution |
| Radionuclide identification (gamma spectrometry) | 720 keV and 511 keV annihilation gamma lines present |
| Radionuclidic Purity (gamma spectrometry) | >95% |
| Chemical purity (ICP-OES) | t.b.d. |
| Molar activity (ICP-OES) | t.b.d. |
| Apparent Molar Activity | t.b.d. |
| Microbiological quality | Bioburden and endotoxin burden can be analysed post release, upon request. |
| Bacterial endotoxin | Bioburden and endotoxin burden can be analysed post release, upon request. |
| pH (pH strips) | Depends on chemical form |
| Additional information | |
| Activity available | ~0.5 GBq |
| Activity limit for UN2910 (excepted package) shipment | 20 MBq in dry state or 2 MBq in liquid form |
| Other information | - |
