BIOEMTECH

Advanced preclinical imaging systems and preclinical CRO services for quantitative assessment and validation of novel radiolabelled compounds

Biomedical services

BIOEMTECH is located in Athens, Greece. BIOEMTECH’s mission is to accelerate preclinical research of promising drugs, towards clinical translation, through precisely targeted services and products. BIOEMTECH leverages its own boutique laboratories to drive innovation and ensure quality, for evaluating new compounds in all stages of preclinical testing, GLP toxicology and alpha emitters therapy schemes. It has developed the eyesTM desktop cameras for real-time in vivo imaging of SPECT and PET radionuclides. The eyesTM offer unmatched excellence in the challenging in vivo imaging of alpha emitters (212Pb & 225Ac) for oncological models, in short scanning times and clinically relevant doses. Both in BIOEMTECH’s services and products, fast screening applications are a core company value towards accelerating drug development.

BIOEMTECH Laboratories provide specialised services to pharmaceutical companies and academic/research institutions. Specifically, it provides a unique infrastructure and platform for preclinical studies for mice and rats in a GLP environment, starting from a cell level and going up to the in vivo

level – all in just one lab, door-by-door. BIOEMTECH’s Radiochemistry laboratory is a licensed facility, to import and handle a wide range of radionuclides and has long established collaboration with the top radionuclide providers worldwide. BIOEMTECH Animal Facility is a registered user establishment (EL25 BIOexp045) for mice and rats, according to national legislation (PD 56/2013) which adopts European Directive 63/2010/EU. The Animal Facility includes the Mice room, the Rats room, the Procedures room and closely collaborates with the Imaging Laboratory. Workflows are performed under BSL2 requirements, and animal use is performed under ABSL1+ requirements.

Facility specifications
BIOEMTECH
Athens, Greece
Helpdesk

Experiments available

Radiolabelling assays
Wide range of compounds (incl. QCs)
New protocol set up and conjugation assays
Access to a wide range of clinical radio-pharmaceutical kits, kinetic stability studies
Main equipment: Radio-TLC, Radio-HPLC, Dose calibrator
In vitro Laboratory
BIOEMTECH is a registered purchaser of ATCC (LGC Standards GmbH), having access to a wide variety of cell lines
In vitro studies: binding and internalisation assays, cytotoxicity assays, cell viability, etc.
Standardised in-house protocols
Cell preparation for animal inoculation and development of oncology models
Cell labelling with a variety of compounds (nuclides, nanoparticles, etc) for in vivo monitoring in real time
Main equipment: Class II biological safety cabinet, CO2 incubators, brightfield microscope with fluorescence
In vivo Imaging facility
Advanced experiments on multi-scale level for both diagnostic and therapeutic protocols including live, whole-body imaging
Proprietary eyesTM systems as well as other scanners for small animal imaging: planar live dynamic SPECT (γ- eyeTM, BIOEMTECH), planar live dynamic PET (β-eyeTM, BIOEMTECH), SPECT (γ-CubeTM, Molecubes), PET (β-eyeTM- tomo, BIOEMTECH), optical (φ-eyeTM, BIOEMTECH), CT (X-CubeTM, Molecubes).
Post processing and quantification of imaging data, dosimetry
In vivo GLP toxicology assays (mice and rats)
In vivo therapy efficacy studies
Ex vivo biodistribution studies, GLP histopathology (outsourced)
Animal model development:
Model set-up, including subcutaneous or orthotropic tumour inoculation and relative measurements
Substance administration (intravenous, retroorbital, intraperitoneal, intramuscular, subcutaneous, orogastric, oral, in food/water, in treats, intratracheal, topical)
Surgery (model set-up, aseptic procedures, macro & microsurgical instruments)